Description: Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer...

Off-white powder. Soluble in DMSO. Microtubule polymerization inhibitor. Disrupts F-actin and induces nucleophosmin/B23 translocation, Immunomodulator with antimicrobial, anti-inflammatory and antitumorigenic properties, Induces apoptosis, autophagy and cell cycle arrest at G2/M phase in a range of cancer cell...

Cucurbitacin B is a plant-derived triterpene that has the classic four-ring structure of mammalian steroids. It has diverse effects on mammalian cells, most notably inducing cell cycle arrest or apoptosis in a range of cancer cell lines. Cucurbitacin B inhibits the growth of several breast cancer cell lines (IC50s =...