Description: Schisandrin A, a primary active component extracted from the traditional Eastern medicine Schisandra chinensis, inhibits CYP3A activity, with an IC50 of 6.60 µM and a Ki of 5.83 µM. Target: Autophagy, Virus Protease, P450. Smiles: COc1cc2C[C@H](C)[C@H](C)Cc3cc(OC)c(OC)c(OC)c3-c2c(OC)c1OC

Schisandrin A is a lignan that has been found in Schisandra and has diverse biological activities. It binds to adiponectin receptor 2 (IC50 = 3.2 µM). Schisandrin A (10, 20, and 50 µM) reduces LPS-induced production of nitric oxide (NO), IL-6, and TNF-alpha and apoptosis in primary mouse microglial cells. It...