Description: Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity. Target: TNF, PDE. Smiles: NC1=CC(=CNC1=O)C=2C=CN=CC2. References: Kobayashi T, et al. J Hepatol. 2002 Jul, 37(1):31-8.

Amrinone is an inhibitor of phosphodiesterase 3 (PDE3, IC50 = 19.5 µM). It increases developed tension and contractile force in isolated cat papillary muscle. Amrinone (1-10 mg/kg) has positive inotropic effects, increasing the rate and force of heart contraction in anesthetized and unanesthetized dogs.Formal Name:...

White to off-white powder. Selective phosphodiesterase III inhibitor. A nonglycoside, noncatecholamine agent with positive inotropic effect. Inhibits cyclic AMP-dependent protein kinase activity by competing with ATP but not cyclic AMP binding sites. It also inhibits platelet aggregation and induces disaggregation.