Amrinone is an inhibitor of phosphodiesterase 3 (PDE3, IC50 = 19.5 µM). It increases developed tension and contractile force in isolated cat papillary muscle. Amrinone (1-10 mg/kg) has positive inotropic effects, increasing the rate and force of heart contraction in anesthetized and unanesthetized dogs.Formal Name:...

White to off-white powder. Selective phosphodiesterase III inhibitor. A nonglycoside, noncatecholamine agent with positive inotropic effect. Inhibits cyclic AMP-dependent protein kinase activity by competing with ATP but not cyclic AMP binding sites. It also inhibits platelet aggregation and induces disaggregation.