Description: Puromycin aminonucleoside (NSC-3056) increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner. Target: Apoptosis, Aminopeptidase, Antibacterial, Proteasome, Antibiotic. Smiles: CN(C)c1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](N)[C@H]1O. References: Lacalle RA, et al....

Puromycin (Cay-13884) is an aminonucleoside antibiotic that blocks protein synthesis in both prokaryotes and eukaryotes by causing premature termination of nascent polypeptide chains. Puromycin aminonucleoside (PANS) is the aminonucleoside portion of puromycin. This analog cannot inhibit protein synthesis or induce...

Puromycin aminonucleoside is a semi-synthetic derivative of puromycin lacking the methoxyphenylalanyl moiety. Puromycin aminonucleoside is the key intermediate in the synthesis of semi-synthetic analogues of puromycin. It does not inhibit protein synthesis or induce apoptosis but exhibits antitumor properties....

Puromycin derivative that has antibiotic and antineoplastic properties, can cause nephrosis.