Description: 7-Methylguanine, a metabolite of DNA methylation, is generated by methylating agents. It is utilized as a probe for DNA-protein interactions and serves as a crucial component in DNA sequencing methods. Target: Others. Smiles: Cn1cnc2nc(N)[nH]c(=O)c12. References: Lee S, et al. Synthesis and structure of...

7-Methylguanine is a metabolite of the natural purine base whose N9 position is available for chemical modifications. This genotoxic adduct can be generated by DNA methylation and has been used as a probe of protein-DNA interactions and for DNA sequencing methods. It is also considered to be a carcinogenic biomarker...

White powder. Soluble in DMSO. Integral part of the cap structure of mRNA necessary for the attachment of the nucleic acids to the ribosome. Has binding affinity to guanine deaminase, an important metalloenzyme in purine catabolism. Found in urine of patients with malignant cancer, suggesting an important role.