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Item number: Cay21267-10

Topiroxostat is an inhibitor of xanthine oxidoreductase (IC50 = 5.3 nM). It inhibits ATP-binding cassette transporter 2 (ABCG2) in isolated human plasma (IC50 = 0.18 µM). Topiroxostat (5 µM) also increases LPS-induced decreases in B cell lymphoma 2 (Bcl-2) levels and decreases LPS-induced increases of Bax and...

Keywords:	FYX-051, 4-[3-(4-pyridinyl)-1H-1,2,4-triazol-5-yl]-2-pyridinecarbonitrile
Application:	Xanthine dehydrogenase/oxidase inhibitor, ABCG2 inhibitor
CAS	577778-58-6
MW:	248.2 D

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