Description: BHPI is a potent ERalpha inhibitor that blocks nuclear estrogen-ERalpha-regulated gene expression effectively. It triggers sustained ERalpha-dependent activation of the endoplasmic reticulum (EnR) stress sensor, notably the unfolded protein response (UPR), and consistently inhibits protein synthesis....

BHPI is an antagonist of estrogen receptor alpha (ERalpha) that blocks 17beta-estradiol-induced proliferation of drug-resistant breast, endometrial, and ovarian cancer cell lines at concentrations ranging from 10 to 1,000 nM. It is effective in vivo, driving tumor regression in mice bearing MCF-7 xenografts at a...