Quinidine is a dextrorotatory stereoisomer of Quinine with anti-malarial, anti-arrhythmic (class 1A), anti-inflammatory, anti-cancer and anti-viral properties. Quinidine acts as a blocker of voltage-gated sodium channels. Inhibition of the Nav1.5 channel is specifically involved in its anti-arrhythmic effects as a...

Quinidine is a stereoisomer of the antimalarial agent quinine (Cay-23958) and a class Ia antiarrhythmic agent. Quinidine blocks the voltage-gated sodium (Nav) channel Nav1.5 in a use-dependent manner. It decreases the amplitude and duration of action potentials in isolated canine ventricular myocytes. It inhibits...