Description: Methyldopa (MK-351), an alpha-adrenergic agonist (selective for alpha2-adrenergic receptors) psychoactive medicine, is served as an antihypertensive or sympatholytic. Target: Adrenergic Receptor, Dopamine Receptor. Smiles: C([C@](C(O)=O)(C)N)C1=CC(O)=C(O)C=C1. References: Head GA. Ann N Y Acad Sci....

L-(-)-alpha-Methyldopa is a dopamine (DOPA) decarboxylase inhibitor (ED50 = 21.8 mg/kg) and has antihypertensive activity in vitro and in vivo. L-(-)-alpha-Methyldopa enters the CNS and is metabolized to form alpha-methylnorepinephrine which acts as an agonist at alpha2-adrenergic receptors. Formulations containing...