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Item number: TGM-T3716-100mg

Description: Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity...

Keywords:	SCH619734
Application:	Targets tachykinin receptor 1 (TACR1)
CAS	552292-08-7
MW:	500.48 D

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Rolapitant

Item number: Cay23906-10

Rolapitant is a potent neurokinin-1 (NK1) receptor antagonist (Ki = 0.66 nM for the human receptor). It is greater than 1,000-fold selective for NK1 over NK2 and NK3 and lacks activity in a panel of 100 receptors, transporters, enzymes, and ion channels. Rolapitant inhibits GR-73632-induced calcium efflux in CHO...

Keywords:	(5S,8S)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one
Application:	Antiemetic, Neurokinin NK1 antagonist
CAS	552292-08-7
MW:	500.5 D

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