Description: 1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesity-related transcription through a feedback mechanism that regulates the expression...

Prunetin is an isoflavone that has been found in P. yedoensis and has diverse biological activities. It is an allosteric inhibitor of hamster liver aldehyde dehydrogenase 2 (ALDH2, IC50 = 0.45 µM) and an antagonist of the progesterone receptor when used at concentrations of 25 and 50 µM. It has estrogenic activity...