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(±)-Nutlin-3
Item number: Cay10004372-5
(±)-Nutlin-3 is a racemic mixture of the p53-Mdm2 protein-protein interaction inhibitor (-)-nutlin-3 (Cay-18585) and its less active enantiomer (+)-nutlin-3 (Cay-10009816). In vivo, (±)-nutlin-3 (200 mg/kg twice daily) reduces tumor volume in an SJSA-1 osteosarcoma mouse xenograft model.Formal Name:...
| Keywords: | rel-4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-pi... |
| Application: | Cell cycle arrest promotor |
| CAS | 548472-68-0 |
| MW: | 581.5 D |
From 52.00€
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Nutlin-3
Item number: TGM-T2158-100mg
Description: Nutlin-3 is an MDM2 antagonist that inhibits MDM2-p53 interaction (Ki=90 nM) and activates p53. Nutlin-3 binds preferentially to the p53-binding pocket of MDM2, leading to stabilization of p53 and activation of the p53 pathway. Nutlin-3 has antitumor activity. Target: E1/E2/E3 Enzyme. Smiles:...
| Keywords: | Nutlin3 |
| Application: | Cell cycle arrest promotor |
| CAS | 548472-68-0 |
| MW: | 581.49 D |
From 55.00€
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Nutlin-3
Item number: LKT-N8277.1
Imidzoline derivative, MDM2 inhibitor.
| Keywords: | Nutlin3 |
| Application: | Imidzoline derivative, MDM2 inhibitor |
| CAS | 548472-68-0 |
| MW: | 581.49 D |
From 86.00€
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