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U-0521
U-0521

Item number: TGM-T29029-100mg

Description: U-0521, an inhibitor of catechol-O-methyltransferase (COMT), enhances the availability and utilization of levodopa in the brain. Target: Others. Smiles: CC(C)C(=O)c1ccc(O)c(O)c1. References: Cumming P, Boyes BE, Martin WR, Adam M, Ruth TJ, McGeer EG. Altered metabolism of [18F]-6-fluorodopa in the...
Application: COMT / tyrosine hydroxylase inhibitor
CAS 5466-89-7
MW: 180.2 D
From 223.00€ *
Review
U-0521
U-0521

Item number: Cay36314-100

U-0521 is an inhibitor of catechol-O-methyltransferase (COMT, Ki = 7.8 µM for the rat liver enzyme) and tyrosine hydroxylase (IC50 = 1 µM for the rabbit adrenal enzyme). It enhances epinephrine-induced contractions of isolated rabbit atria when used at a concentration of 55 µM. U-0521 (41.5 µmol/kg) also enhances...
Keywords: 3',4'-Dihydroxy-2-methylpropiophenone, NSC 27389, 1-(3,4-dihydroxyphenyl)-2-methyl-1-propanone
Application: COMT / tyrosine hydroxylase inhibitor
CAS 5466-89-7
MW: 180.2 D
From 130.00€ *
Review