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Item number: TGM-T84413-10mg

Description: PD 0332991, an unsymmetrical indolocarbazole compound, is cell-permeable and exhibits antiproliferative effects by functioning as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk4/D1 (IC 50 = 76 nM). Although it can inhibit other Cdks, such as Cdk2/E and Cdk1/B, effectiveness...

Keywords:	Cyclin-dependent kinase 4 Inhibitor
Application:	Cdk4 inhibitor
CAS	546102-60-7
MW:	404.2 D

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Cdk4 Inhibitor

Item number: Cay17648-1

Cdk4 inhibitor is a cell-permeable, asymmetrical indolocarbazole that exhibits antiproliferative activity by blocking cyclin D1/Cdk4 with an IC50 value of 0.8 µM. It is selective for cyclin D1/Cdk4, demonstrating 7-fold and 28-fold weaker activity against cyclin E/Cdk2 and cyclin B/Cdk1, respectively, and little...

Keywords:	Cyclin-dependent kinase 4 Inhibitor, 2-bromo-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
Application:	Cell-permeable Cdk4 inhibitor
CAS	546102-60-7
MW:	404.2 D

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