Etretinate is a second-generation retinoid previously used systemically to manage psoriasis but withdrawn due to teratogenicity. Etretinate alters cAMP signaling, which may be defective in psoriasis.Formal Name: (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid, ethyl ester....

Etretinate, also known as Tegison, is a synthetic aromatic analog of retinoic acid. It is used for treatment of severe recalcitrant psoriasis, parakeratotic skin disorders, chemoprevention of skin cancer and other neoplasia.