Description: Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for preventing/counteracting diabetic encephalopathy. Target: HDAC, Akt, transporter,...

Marein is a glucoside chalcone that has been found in C. tinctoria and has diverse biological activities, including antioxidant, enzyme inhibitory, antidiabetic, and anti-inflammatory properties. It scavenges DPPH (Cay-14805) radicals (IC50 = 48.35 µM) in a cell-free assay and is an inhibitor of EGFR (IC50 = 19.94...