A23187 is a calcium ionophore and a microbial metabolite that has been found in S. chartreusensis. It induces calcium overload and mitochondrial apoptosis in HEK293 cells when used at a concentration of 5 µM. A23187 (5 µM) induces the production of reactive oxygen species (ROS) and neutrophil extracellular trap...

Description: Calcimycin (A-23187) is an ionophorous, polyether carboxylic antibiotic from Streptomyces chartreusensis. It binds and transports calcium and other divalent cations across membranes, uncouples oxidative phosphorylation, and inhibits ATPase of rat liver mitochondria. The substance is primarily used as a...

Calcimycin induces apoptosis in the lens epithelium which leads to opacification.

Antibiotic A23187 is a calcium ionophore. It causes rapid influx of calcium in various cells across biological membranes. Appearance: Off white solid , Melting Point: 181-182°C, Purity: > 98% (TLC), Solubility: Soluble in DMSO , (50mg/ml with sonication) , Storage and Stability: Lyophilized powder may be stored at...

Antibiotic A23187 is a calcium ionophore. It causes rapid influx of calcium in various cells across biological membranes. Appearance: Off white solid , Melting Point: 181-182°C, Purity: > 98% (TLC), Solubility: Soluble in DMSO , (50mg/ml with sonication) , Storage and Stability: Lyophilized powder may be stored at...