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SW044248
Item number: TGM-T3181-100mg
Description: SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells. Target: Topoisomerase. Smiles: CCC(Sc1nnc2c3ccccc3n(CC)c2n1)C(=O)Nc1ccccc1OC. References: Zubovych IO, et al. Mol Y Ther. 2016 Jan,15(1):23-36.
| Application: | DNA topoisomerase I inhibitor |
| CAS | 522650-83-5 |
| MW: | 421.52 D |
From 37.00€
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SW044248
Item number: Cay23459-5
SW044248 is a DNA topoisomerase I inhibitor that exhibits selective cytotoxicity across a panel of 46 non-small cell lung cancer cell (NSCLC) lines (IC50s = ~2 µM for HCC4017, H292, and H1819 cells versus >20 µM for the remaining cell lines). It induces cleavage of poly(ADP-ribose) polymerase (PARP) and caspase-3...
| Keywords: | 2-[(5-ethyl-5H-1,2,4-triazino[5,6-b]indol-3-yl)thio]-N-(2-methoxyphenyl)-butanamide |
| Application: | DNA topoisomerase I inhibitor |
| CAS | 522650-83-5 |
| MW: | 421.5 D |
From 87.00€
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