Autophagy is a multi-step process that involves the degradation and digestion of intracellular components by the lysosome. This process allows cells to efficiently mobilize and recycle cellular constituents, and also prevents the accumulation of damaged organelles, misfolded proteins, and invading microorganisms....

Description: 3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kgamma (IC50 = 60 µM) and class III VPS34 (IC50 = 25 µM). 3-Methyladenine inhibits autophagy. Target: PI3K, Autophagy, Mitophagy, Endogenous Metabolite. Smiles: Cn1cnc(N)c2ncnc12. References: Hou H, et al. Inhibitors of...

White to off-white solid. Soluble in DMSO, DMF, ethanol or water. Potent cell permeable and selective inhibitor of phosphatidyl-inositol 3-kinase (PI3K), Blocks class I, class II and class III PI3Ks, including some downstream targets, Blocks class I PI3K persistently and class III PI3K transiently, Induces autophagy...

White to off-white powder. Soluble in DMSO (10 mg/ml), water (5 mg/ml), DMF (10 mg/ml) or ethanol. Used to inhibit and study the mechanism of autophagy (lysosomal self-degradation) and apoptosis under various conditions. Inhibits autophagy by blocking autophagosome formation via the inhibition of type III...

3-Methyl adenine is an autophagy inhibitor that also inhibits DNA polymerase activity and DNA synthesis if incorporated into DNA. Additionally, 3-methyl adenine exhibits antioxidative benefit, decreasing levels of lactate dehydrogenase and ROS/RNS in hydroquinone- and rapamycin-treated cells.