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Item number: TGM-T14900-100mg

Description: CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM). Target: CCR. Smiles: CC(=O)C1=C(O)C(=O)N([C@@H]1C1CCCCC1)c1ccc(Cl)cc1F. References: Zweemer AJ, et al. Multiple binding sites for small-molecule antagonists at the CC chemokine receptor 2. Mol Pharmacol. 2013...

Application:	Allosteric CCR2 antagonist
CAS	512177-83-2
MW:	351.8 D

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CCR2-RA-[R]

Item number: Cay28423-1

CCR2-RA-[R] is an allosteric antagonist of chemokine (C-C motif) receptor 2 (CCR2, IC50 = 103 nM). It inhibits [35S]GTPgammaS binding and beta-arrestin recruitment induced by chemokine (C-C motif) ligand 2 (CCL2) in U2OS membranes and cells, respectively, expressing CCR2 (IC50s = 24 and 25 nM, respectively).Formal...

Keywords:	(5R)-4-acetyl-1-(4-chloro-2-fluorophenyl)-5-cyclohexyl-1,5-dihydro-3-hydroxy-2H-pyrrol-2-one
Application:	Allosteric CCR2 antagonist
CAS	512177-83-2
MW:	351.8 D

From 68.00€ *

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