Description: Echinomycin is a cell-permeable hypoxia-inducible factor-1 (HIF-1) DNA-binding activity inhibitor. Echinomycin selectively inhibits the cancer stem cells (CSCs, IC50: 29.4 pM). Target: Others. Smiles:...

Antibiotic, Antitumor compound, Powerful, selective inhibitor of nucleic acid synthesis in vitro, Potent hypoxia-inducible factor 1 (HIF-1) DNA binding activity inhibitor, Apoptosis inducer, Antibacterial, antifungal and antiviral. Isolated from Streptomyces echinatus (DSM 40013).

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that controls genes involved in glycolysis, angiogenesis, migration, and invasion. Echinomycin is a cell-permeable inhibitor of HIF-1-mediated gene transcription. It acts by intercalating into DNA in a sequence-specific manner, blocking the binding of...

Quiniomycin A is a cyclic depsipeptide metabolite. It has broad activity against bacteria, fungi and viruses and has found application as an antitumor agent. Quinomycin A acts by bifunctional intercalation of nucleic acids. Recent research has shown quinomycin A to be an extremely potent inhibitor of...