- Search results for 49843-98-3
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2 products were found matching "49843-98-3"!
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Item number: Cay10009798-5
EX-527 is an inhibitor of sirtuin 1 (SIRT1, IC50 = 0.098 µM). It is selective for SIRT1 over SIRT2, and SIRT3 (IC50s = 19.6 and 48.7 µM, respectively) and the cytochrome P450 (CYP) isoforms CYP3A4, CYP2D6, CYP2C9, CYP2C19, and CYP1A2 at 1 µM. EX-527 (50 µM) induces cell cycle arrest at the G1 phase in MCF-7...
Keywords: | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide |
Application: | SIRT1 inhibitor |
CAS | 49843-98-3 |
MW: | 248.7 D |
From 43.00€
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Item number: LKT-E9201.25
EX 527 is an inhibitor of sirtuin 1 (SIRT1), sirtuins are considered class III histone deacetylases (HDACs). EX 527 binds the NAD+ site of sirtuin 1, stabilizing a closed conformation. EX 527 exhibits immunostimulatory and anti-inflammatory activities. In animal models of autoimmune colitis and inflammatory bowel...
Keywords: | Selisistat |
Application: | SIRT1 inhibitor |
CAS | 49843-98-3 |
MW: | 248.71 D |
From 128.00€
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