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Genz-123346 free base
Genz-123346 free base

Item number: TGM-T4049-100mg

Description: Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1. Target: Glucokinase. Smiles: CCCCCCCCC(=O)N[C@H](CN1CCCC1)[C@H](O)c1ccc2OCCOc2c1. References: Zhao H, et al. Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal...
Application: Glucosylceramide synthase (ceramide glucosyltransferase) inhibitor
CAS 491833-30-8
MW: 418.57 D
From 43.00€ *
Review
Genz-123346
Genz-123346

Item number: Cay28500-100

Genz-123346 is a glucosylceramide synthase inhibitor (IC50 = 14 nM). It reduces hepatic levels of glucosylceramide and triglycerides as well as blood levels of alanine aminotransferase (ALT), hemoglobin A1c, and non-fasting glucose in ob/ob mice when administered at a dose of 120 mg/kg per day. Genz-123346 (125...
Keywords: N-[(1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]-nonanamide
Application: Glucosylceramide synthase (ceramide glucosyltransferase) inhibitor
CAS 491833-30-8
MW: 418.6 D
From 175.00€ *
Review