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Item number: TGM-T7130-100mg

Description: Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking in animal models, characteristics that may be beneficial in the treatment of conditions with unbalanced pulmonary neutrophilia. Target:...

Keywords:	MK-7123, SCH 527123
Application:	Allosteric CXCR1 antagonist
CAS	473727-83-2
MW:	397.42 D

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SCH 527123

Item number: Cay27800-1

SCH 527123 is an allosteric antagonist of C-X-C chemokine receptor type 1 (CXCR1, IC50 = 43 nM in Ba/F3 cells) and CXCR2 (IC50 = 0.97 nM in HTS cells). It inhibits calcium flux induced by CXCL8 in Ba/F3 cells expressing human recombinant CXCR1 or CXCR2. SCH 527123 (3 nM) inhibits CXCL8-induced chemotaxis of Ba/F3...

Keywords:	MK-7123, 2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]-benzamide
Application:	Allosteric CXCR1 antagonist
CAS	473727-83-2
MW:	397.4 D

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