Description: Betulin (betulinol) (lup-20(29)-ene-3beta, 28-diol) is an abundant, naturally occurring triterpene. It is commonly isolated from the bark of birch trees where it forms up to 30% of the dry weight of the extractive and is found in birch sap as well. Target: Lipid, Apoptosis, Endogenous Metabolite,...

Sterol regulatory element binding protein 2 (SREBP-2) regulates cholesterol synthesis by activating the transcription of genes for HMG-CoA reductase and other enzymes of the cholesterol synthetic pathway. When cellular sterol levels are high, SREBP is bound by SCAP and Insig to ER membranes as a glycosylated...

White solid. Soluble in DMSO, DMF or ethanol. Specific SREBPs (sterol regulatory element-binding proteins) inhibitor. Inhibits ER-Golgi translocation of SREBPs through binding to SCAP in an INSIG-dependent manner, Improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques. Lowers cholesterol...

Pentacyclic triterpene found in various plant sources.