Betulinic acid is a natural plant triterpenoid that is structurally related to mammalian bile acids. It is an agonist of the G protein-coupled bile acid receptor TGR5 (EC50 = 1 µM), which might be linked with its ability to alter gene expression and fatty liver development in cells and mice given ethanol. Betulinic...

Isolated from Platanus acerifolia bark. Anti-HIV compound. Anticancer compound. Apoptosis inducer. Modulator of NF-kappaB. Potent DNA topoisomerase II inhibitor. Potent proteasome activator. Antimalarial compound.

Isolated from Platanus acerifolia bark. Anti-HIV compound. Anticancer compound. Apoptosis inducer. Modulator of NF-kappaB. Potent DNA topoisomerase II inhibitor. Potent proteasome activator. Antimalarial compound.

White powder. Soluble in DMSO (20mg/ml) or DMF (15mg/ml). Chemical. CAS: 472-15-1. Formula: C30H48O3. MW: 456.71. Betulinic acid is a natural plant triterpenoid. It has been shown to have anticancer, apoptotic, anti-inflammatory, antiobesity, antimalarial and anti-HIC properties. It has been described as a potent...

Betulinic acid is a naturally occurring pentacyclic triterpenoid which has anti-retroviral, anti-malarial, and anti-inflammatory properties, as well as a more recently discovered potential as an anticancer agent, by inhibition of topoisomerase.