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BMS-536924
Item number: TGM-T6419-1mg
Description: BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2. Target: Src, IGF-1R, FAK, MEK, Apoptosis. Smiles: Cc1cc(cc2nc([nH]c12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCOCC1....
| Keywords: | CS-0117, HY-10262, BMS 536924, HY-10262 |
| Application: | IGF1R / insulin receptor inhibitor |
| CAS | 468740-43-4 |
| MW: | 479.96 D |
From 34.00€
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BMS-536924
Item number: Cay14666-1
BMS-536924 is a dual inhibitor of insulin-like growth factor receptor (IGF-1R) kinase and insulin receptor (IC50s = 100 and 73 nM, respectively). In this way, it blocks IGF-1R autophosphorylation and signaling through MEK1/2 and Akt, leading to G1 arrest and apoptosis in myeloblastic leukemia ML-1 cells. BMS-536924...
| Keywords: | 4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinone |
| Application: | IGF1R / insulin receptor inhibitor |
| CAS | 468740-43-4 |
| MW: | 480 D |
From 67.00€
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