3 products were found matching "457081-03-7"!
No results were found for the filter!
Pyridone 6
Item number: TGM-T3080-100mg
Description: Pyridone 6 (JAK Inhibitor)(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM), displaying significantly weaker affinities (130 nM to 10 mM) for other protein tyrosine kinases. Target: JAK, Tyrosine Kinases. Smiles:...
| Keywords: | CMP 6, JAK Inhibitor, JAK Inhibitor I, Janus-Associated Kinase Inhibitor I |
| Application: | JAK2, JAK3, JAK1 inhibitor |
| CAS | 457081-03-7 |
| MW: | 309.34 D |
From 75.00€
*
JAK Inhibitor I
Item number: Cay15146-1
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. JAK1 mostly activates IL-6, whereas JAK1 and JAK3 trigger IL-2 and IL-4 and JAK1 and JAK2 stimulates IFN-gamma. JAK Inhibitor I is a pyridine-containing...
| Keywords: | CMP 6, Janus-Associated Kinase Inhibitor I, Pyridone 6,... |
| Application: | JAK2, JAK3, JAK1 inhibitor |
| CAS | 457081-03-7 |
| MW: | 309.3 D |
From 40.00€
*
Merck-5
Item number: SYN-1054-M001
Soluble in DMSO. Merck 5, also known as Pyridone 6, is a potent and reversible ATP-competitive inhibitor of the JAK kinases (JAK1, JAK2, JAK3, and Tyk2) with IC(50) values in the low anomolar range. At higher values (IC(50) >100nM) Merck 5 also can inhibit ERK kinase family and appear to block IL-2 and IL-4...
| Keywords: | Pyridone 6 |
| Application: | JAK / Tyk2 inhibitor |
| CAS | 457081-03-7 |
| MW: | 309,3 D |
From 300.00€
*
