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AV-412 free base
Item number: TGM-TQ0293-2mg
Description: AV-412 free base is an EGFR inhibitor (IC50s: 0.75, 0.79, 0.5, 2.3, 19 nM for EGFR, EGFR(T790M), EGFR(L858R), EGFR(L858R/T790M) and ErbB2). Target: EGFR. Smiles: CN1CCN(CC1)C(C)(C)C#Cc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C. References: Suzuki T, et al. Pharmacological characterization of MP-412...
| Keywords: | MP-412 free base |
| Application: | EGFR / ErbB2 inhibitor |
| CAS | 451492-95-8 |
| MW: | 507 D |
65.00€
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AV-412
Item number: SYN-1012-M001
Soluble in DMSO or ethanol. AV-412 is a potent dual inhibitor of EGFR and ErbB2 tyrosine kinases, including the mutant EGFR(L858R,T790M), which is clinically resistant to the EGFR-specific kinase inhibitors erlotinib and gefitinib. In enzyme assays assay the compound inhibited the EGFR variants and ErbB2 in the...
| Keywords: | MP-412, AV412 |
| Application: | EGFR / ErbB2 inhibitor |
| CAS | 451492-95-8 |
| MW: | 507 D |
From 293.00€
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