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Item number: TGM-T7162-2mg

Description: R1487 Hydrochloride (R1487 (Hydrochloride)) is an orally bioavailable and highly selective inhibitors of p38alpha. Target: Autophagy, p38 MAPK. Smiles: Cl.Cn1c2nc(NC3CCOCC3)ncc2cc(Oc2ccc(F)cc2F)c1=O. References: Goldstein DM, Soth M, Gabriel T,et al.Discovery of...

Keywords:	R1487 (Hydrochloride)
Application:	p38alpha / MAPK14 inhibitor
CAS	449808-64-4
MW:	424.83 D

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R1487 (hydrochloride)

Item number: Cay31478-1

R1487 is an inhibitor of p38alpha MAPK (IC50 = 10 nM). It is selective for p38alpha over p38beta MAPK (Kds = 0.2 and 29 nM, respectively), as well as a panel of 306 additional kinases at 10 µM, but does inhibit 11 kinases by greater than 85% at 10 µM. R1487 inhibits LPS-induced IL-1beta production in isolated human...

Keywords:	6-(2,4-difluorophenoxy)-8-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-pyrido[2,3-d]pyrimidin-7(8H)-one, monohydrochloride
Application:	p38alpha / MAPK14 inhibitor
CAS	449808-64-4
MW:	424.8 D

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