Description: VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively). Target: S1P Receptor, LPL Receptor. Smiles: CCCCCCCCc1cccc(NC(=O)[C@H](N)COP(O)(O)=O)c1. References: Davis...

Sphingosine-1-phosphate (S1P, Cay-62570) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its activity by binding to five distinct G protein-coupled receptors, S1P1/EDG-1,...