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Item number: TGM-T7506-100mg

Description: Yoda 1 is an agonist of the Piezo1 channel that agonizes human- and mouse-derived Piezo1 (EC50=17.1/26.6 µM). Yoda 1 is also an inhibitor of glycine transporter protein 2 (GlyT2). Target: Piezo Channel. Smiles: Clc1cccc(Cl)c1CSc1nnc(s1)-c1cnccn1. References: Ruhma S , Jie X , Dubin A E , et al. Chemical...

Application:	Piezo1 agonist
CAS	448947-81-7
MW:	355.27 D

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Yoda1

Item number: Cay21904-1

Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 µM for murine and human Piezo1-transfected HEK293T cells, respectively). It is selective for Piezo1 as it elicits Ca2+ flux in Piezo1- but not Piezo2-transfected HEK293T cells. Yoda1 slows the inactivation phase of murine Piezo1 transient currents and...

Keywords:	2-[5-[[(2,6-dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]-pyrazine
Application:	Piezo1 agonist
CAS	448947-81-7
MW:	355.3 D

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