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Item number: Cay23304-100

Macitentan is a dual antagonist of the endothelin (ET) receptors type A and B (IC50s = 0.5 and 391 nM in a radioligand binding assay using recombinant ETA and ETB, respectively). Macitentan inhibits intracellular Ca2+ increases induced by the endothelin isoform ET-1 in human pulmonary arterial smooth muscle cells...

Keywords:	ACT-064992, N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propyl-sulfamide
Application:	Dual EDNRA / EDNRB antagonist
CAS	441798-33-0
MW:	588.3 D

From 54.00€ *

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Macitentan

Item number: LKT-M0009.1

Macitentan is a dual endothelin receptor (ET-A/B)antagonist that displays antihypertensive, anti-fibrotic, and anticancer activity, this compound exhibits slower receptor dissociation kinetics than other endothelin receptor antagonists. Macitentan is currently used to treat pulmonary arterial hypertension, as...

Keywords:	ACT-064992, Actelion-1
Application:	Endothelin receptor type A antagonist, Endothelin receptor type B antagonist
CAS	441798-33-0
MW:	588.27 D

From 73.00€ *

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