Description: WAY-200070 is a specific agonist of estrogen receptor beta (ERRbeta, IC50: 2.3 nM). Target: Estrogen/progestogen Receptor, Estrogen Receptor/ERR. Smiles: BrC1=C2C(N=C(O2)C3=CC=C(O)C=C3)=CC(O)=C1. References: Hughes ZA, et al. WAY-22020070, a selective agonist of estrogen receptor beta as a potential...

WAY-200070 is a potent and selective agonist of estrogen receptor beta (ERbeta, IC50s = 2 and 187 nM for human full-length ERbeta and ERalpha, respectively). WAY-200070 (30 mg/kg, s.c. in mice) induces nuclear translocation of ERbeta and increases c-fos activation and dopamine levels in the striatum four hours after...