Description: BRL-50481 is a novel and selective PDE7 inhibitor with IC50 values of 0.15 µM for PDE7A, 12.1 µM for PDE7B, 62 µM for PDE4, and 490 µM for PDE3. Target: PDE. Smiles: CN(C)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O. References: Safavi M, et al. New methods for the discovery and synthesis of PDE7 inhibitors as new...

BRL 50481 is a potent, selective inhibitor of phosphodiesterase (PDE) 7, inhibiting human recombinant PDE7A1 with a Ki value of 180 nM. It is much less effective against PDE3 and PDE4 and is without effect against PDE1B, PDE1C, PDE2, and PDE5. Through its effects on PDE7A1, BRL 50481 enhances the inhibitory effects...