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Item number: TGM-T4253-100mg

Description: Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation. Target: E1/E2/E3 Enzyme, Others. Smiles: OC(=O)COc1ccc(Br)cc1\C=C1/SC(=S)N(Cc2cccnc2)C1=O. References: Wu L, et al. Specific small molecule inhibitors of Skp2-mediated p27 degradation. Chem...

Keywords:	SKPin C1
Application:	Skp2 inhibitor
CAS	432001-69-9
MW:	465.34 D

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SKPin C1

Item number: Cay26141-5

SKPin C1 is an inhibitor of Skp1-Cullin1-F-box (SCF) family protein Skp2-mediated p27 degradation. It binds to Skp2 at the Cdc kinase subunit 1 (Cks1) interaction interface and blocks ubiquitylation of p27 in a Cks1-dependent manner in vitro when used at a concentration of 50 µM. SKPin C1 increases nuclear...

Keywords:	2-[4-bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]-acetic acid
Application:	Skp2-mediated p27 degradation inhibitor
CAS	432001-69-9
MW:	465.3 D

From 112.00€ *

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