Description: Nitrocefin is an antibiotic. It being sensitive to hydrolysis by all lactamases produced by gram-positive and gram-negative bacteria. Target: Others. Smiles: OC(=O)C1=C(CS[C@@H]2[C@H](NC(=O)Cc3cccs3)C(=O)N12)\C=C\c1ccc(cc1[N+]([O-])=O)[N+]([O-])=O. References: Boehle KE, Gilliand J, Wheeldon CR, Holder...

The generation of beta-lactamases by bacteria affords resistance to several classes of beta-lactam antibiotics, including penicillins and cephalosporins. Nitrocefin is a chromogenic cephalosporin substrate commonly used to detect beta-lactamases in bacteria. The presence of beta-lactamase activity is indicated by...