Description: Potent endogenous neuropeptide S receptor (NSPR) agonist (EC50 = 3.2 nM). Increases locomotor activity and wakefulness in mice. Also reduces anxiety-like behavior in mice. References: Xu et al (2004) Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. Neuron 43 487 PMID:

Neuropeptide S is a neuropeptide that is an agonist of the neuropeptide S receptor (NPSR) with an EC50 value of 3.2 nM for the rat peptide to induce intracellular calcium mobilization in HEK293 cells expressing the human receptor. In rats, it increases the duration of wakefulness and decreases slow wave sleep stage...