Description: Timosaponin AIII (Timosaponin A3) induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 µM). The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC50: 2.5 µM, BT474 cells, 6 µM, MDAMB231). The Timosaponin AIII pro-apoptotic...

Timosaponin AIII (TAIII) is a steroidal saponin isolated from A. asphodeloides that has anticancer, anti-inflammatory, and antithrombotic activities and also improves learning and memory deficits in mice. It inhibits invasive activity and COX-2 gene expression induced by hepatocyte growth factor (HGF) in MDA-MB-231...