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Item number: TGM-T36125-100mg

Description: Tienilic Acid is a uricosuric diuretic with certain hepatotoxicity. Target: P450. Smiles: C(=O)(C1=C(Cl)C(Cl)=C(OCC(O)=O)C=C1)C2=CC=CS2. References: Levron, J.C., et al. Pharmacokinetic study of 2,3-dichloro 4- (2-thienyl keto14C) phenoxyacetic acid (tienilic acid) in animals. European Journal of Drug...

Application:	Targets solute carrier family 12 (sodium/potassium/chloride transporter), member 1 (SLC12A1, NKCC2)
CAS	40180-04-9
MW:	331.17 D

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Tienilic Acid

Item number: Cay10008517-5

Cytochrome P450 enzymes function to metabolize both endogenous and exogenous compounds. Both the 3A and 2C isoforms are present in human liver of which CYP2C9 seems most highly expressed. Tienilic acid is a specific suicide substrate for CYP2C9 and CYP2C10 whereby its oxidation inactivates the enzyme. The time...

Keywords:	[2,3-dichloro-4-(2-thienylcarbonyl)phenoxy]-acetic acid
Application:	CYP2C9 /CYP2C10 substrate
CAS	40180-04-9
MW:	331.2 D

From 99.00€ *

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