Description: SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 µM). Target: JNK. Smiles: Nc1nnc(Sc2ncc(s2)[N+]([O-])=O)s1. References: De SK, et al. Design, synthesis, and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and...

Halicin is a JNK1 inhibitor (IC50 = 0.7 µM). It is selective for JNK1 over p38alpha, Furin, and lethal factor (IC50s = >100, >100, and >50 µM, respectively), as well as Akt at 100 µM. Halicin inhibits TNF-alpha-induced phosphorylation of c-Jun in a cell-based assay (EC50 = 6.23 µM). In vivo, halicin (25 mg/kg)...