Description: Carbidopa monohydrate (S(-)-Carbidopa) is an inhibitor of DOPA decarboxylase, preventing the conversion of levodopa to dopamine. Target: Decarboxylase, Aryl Hydrocarbon Receptor. Smiles: CC(CC1=CC=C(O)C(O)=C1)(NN)C(O)=O. References: Orlefors H, et al. Eur J Nucl Med Mol Imaging. 2006 Jan,33(1):60-5.

Carbidopa inhibits aromatic-L-amino-acid decarboxylase (DOPA Decarboxylase or DDC),an enzyme important in the biosynthesis of L-tryptophan to serotonin and in the biosynthesis of L-DOPA to Dopamine (DA).

Carbidopa is a peripherally restricted inhibitor of dopamine decarboxylase, the enzyme that converts L-DOPA (Cay-13248) to dopamine. Carbidopa (100 mg/kg) pretreatment in dog increases the plasma concentration of L-DOPA by 186% and prolongs the half-life in plasma by 48% and skeletal muscle extracellular fluid by...