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Item number: Cay10009458-10

JTE-013 is a sphingosine-1-phosphate receptor 2 (S1P2) and S1P4 antagonist (IC50s = 17 and 237 nM, respectively). It is selective for S1P2 over S1P1 and S1P3 (IC50s = >10 µM for both). JTE-013 (1 and 10 µM) reverses S1P-induced inhibition of human umbilical vein endothelial cell (HUVEC) and smooth muscle cell (SMC)...

Keywords:	N-(2,6-dichloro-4-pyridinyl)-2-[1,3-dimethyl-4-(1-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-hydrazinecarboxamide
Application:	S1P2 receptor antagonist
CAS	383150-41-2
MW:	408.3 D

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JTE-013

Item number: TGM-T15629-10mg

Description: JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 nM, respectively). Target: S1P Receptor, Apoptosis, LPL Receptor. Smiles: CC(C)c1cc(NNC(=O)Nc2cc(Cl)nc(Cl)c2)nc2n(C)nc(C)c12. References: Li...

CAS	383150-41-2
MW:	408.29 D

From 71.00€ *

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