Description: Maraviroc (Selzentry) is a C-C Chemokine Receptor Type 5 (CCR5) antagonist, and for MIP-1alpha(IC50=3.3 nM), MIP-1beta (IC50=7.2 nM) and RANTES(IC50=5.2 nM).Maraviroc inhibits HIV-1 entry via CCR5 coreceptor interaction. Target: CCR, HIV Protease. Smiles:...

Maraviroc is an antagonist of chemokine (C-C motif) receptor 5 (CCR5, Ki = 0.24 nM for the rhesus monkey recombinant receptor). It inhibits binding of MIP-1alpha, MIP-1beta, and RANTES to HEK293 cell membranes expressing CCR5 (IC50s = 3.3, 7.2, and 5.2 nM, respectively) and inhibits HIV-1 binding to CCR5 via...