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Item number: TGM-T4661-100mg

Description: PKG drug G1 targets PKG Ialpha C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Ialpha-independent mechanism. Target: PKA. Smiles: Cc1[nH]c2ccccc2c1\C=C1/NC(=S)NC1=O. References: Burgoyne JR, et al. Proof of Principle for a Novel Class of Antihypertensives That Target...

Application:	Protein kinase Gialpha activator
CAS	374703-78-3
MW:	257.31 D

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PKG Drug G1

Item number: Cay29768-10

PKG drug G1 is an activator of protein kinase GIalpha (PKGIalpha). It induces relaxation in U-46619-precontracted mesenteric arteries isolated from wild-type, but not oxidation-insensitive Cys42Ser PKGIalpha knock-in, mice in a concentration-dependent manner. PKG drug G1 (14.8 mg/kg) induces oxidation of PKGIalpha,...

Keywords:	5-[(2-methyl-1H-indol-3-yl)methylene]-2-thioxo-4-imidazolidinone
Application:	Protein kinase Gialpha activator
CAS	374703-78-3
MW:	257.3 D

From 43.00€ *

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