Description: Disopyramide (Triombrin) is a class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local...

Disopyramide is a sodium channel blocker that, in rabbit ventricular myocytes, binds and dissociates from open channels more quickly than from resting channels. It is a class Ia antiarrhythmic agent that delays conduction through the AV node and ventricles of the dog heart both in vivo (3 and 5 mg/kg) and in vitro...