Description: AY 9944 is a specific cholesterol biosynthesis inhibitor that targets the 7-dehydrocholesterol Delta7-reductase (DHCR7) enzyme (IC50=13 nM). At high doses, AY 9944 also inhibits sterol Delta7-Delta8 isomerase in cultured embryos, leading to the accumulation of cholest-8-en-3beta-ol[1][2][3]....

AY 9944 prevents cholesterol biosynthesis by inhibiting the 7-dehydro cholesterol Delta7-reductase (DHCR7) enzyme (IC50 = 13 nM), which interferes with the conversion of 7-dehydro cholesterol (Cay-14612) to cholesterol. Furthermore, by upregulating the expression of DHCR7, AY 9944 can block Hedgehog signaling at the...