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Item number: TGM-T5S0803-10mg

Description: Columbamine (Columbamin) shows strong activity with IC5 48.1 µM.Columbamine exerts anti-proliferative and anti-vasculogenic effects on metastatic human osteosarcoma U2OS cells with low toxicity. Target: Others. Smiles: OC=1C=C2C=3[N+](=CC=4C(C3)=CC=C(OC)C4OC)CCC2=CC1OC. References: Bao M , Cao Z , Yu D...

Keywords:	Columbamin, Dehydroisocorypalmine
CAS	3621-36-1
MW:	338.38 D

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Columbamine

Item number: Cay35032-1

Columbamine is an alkaloid that has been found in Plumeria rubra and has diverse biological activities. It is also a metabolite of berberine (Cay-10006427). Columbamine inhibits the cytochrome P450 (CYP) isoform CYP3A4 (IC50 = 30.6 µM). It is active against P. falciparum (IC50 = 1.92 µM). It decreases glucose...

Keywords:	Dehydroisocorypalmine, 5,6-dihydro-2-hydroxy-3,9,10-trimethoxy-dibenzo[a,g]quinolizinium
Application:	Bioactive alkaloid
CAS	3621-36-1
MW:	338.4 D

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