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BMS-378806
Item number: TGM-T6418-100mg
Description: BMS-378806 (BMS-806) selectively inhibits the binding of HIV-1 gp120 to the CD4 receptor with EC50 of 0.85-26.5 nM in virus. Target: HIV Protease, gp120/CD4. Smiles: COc1ccnc2[nH]cc(C(=O)C(=O)N3CCN(C[C@H]3C)C(=O)c3ccccc3)c12. References: Wang T, et al, J Med Chem, 2003, 46(20), 4236-4239.
| Keywords: | BMS-806, BMS378806 |
| CAS | 357263-13-9 |
| MW: | 406.43 D |
From 31.00€
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BMS-806
Item number: Cay18525-1
BMS-806 is a small molecule that inhibits the first step of HIV-1 infection by blocking the binding of host cell CD4 with viral gp120 protein. It binds the exterior envelope glycoprotein gp120 (Kd= 21.1 nM, Ki = 24.9 nM), blocking the conformational change that occurs with CD4 binding and preventing fusion of the...
| Keywords: | BMS-378806, 1-[(2R)-4-benzoyl-2-methyl-1-piperazinyl]-2-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)-1,2-ethanedione |
| Application: | HIV-1 infection blocking, CD4-gp120 binding inhibitor |
| CAS | 357263-13-9 |
| MW: | 406.4 D |
From 61.00€
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