Description: BT2, a BCKDC kinase (BDK) inhibitor, exhibits an IC50 of 3.19 µM and functions as a potent, selective Mcl-1 inhibitor with a Ki value of 59 µM. Its interaction with BDK induces helix movements in the N-terminal domain, leading to BDK's dissociation from the branched-chain alpha-ketoacid dehydrogenase...

3,6-dichloro-benzo[b]thiophene-2-Carboxylic acid is an inhibitor of myeloid cell leukemia 1 (Mcl-1) with a Ki value of 59 µM for binding of FITC-Mcl-1-BH2 peptide binding to Mcl-1. It has been used as a building block in the synthesis of inhibitors of Mcl-1, the toll-like receptor 3/double-stranded RNA (TLR3/dsRNA)...